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retinoic acid receptor, alpha, Mouse, Clone: 2D2, Abnova™
Mouse monoclonal antibody raised against a partial recombinant RARA.
Supplier: Abnova Corporation H00005914M03
Description
Retinoid signaling is transduced by 2 families of nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor (RXR; see MIM 180245), which form RXR/RAR heterodimers. In the absence of ligand, DNA-bound RXR/RARA represses transcription by recruiting the corepressors NCOR1 (MIM 600849), SMRT (NCOR2; MIM 600848), and histone deacetylase (see MIM 601241). When ligand binds to the complex, it induces a conformational change allowing the recruitment of coactivators, histone acetyltransferases (see MIM 603053), and the basic transcription machinery. Translocations that always involve rearrangement of the RARA gene are a cardinal feature of acute promyelocytic leukemia (APL; MIM 612376). The most frequent translocation is t(15,17)(q21;q22), which fuses the RARA gene with the PML gene (MIM 102578) (Vitoux et al., 2007 [PubMed 17468032]).[supplied by OMIM
Sequence: QLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDTLSSpecifications
| retinoic acid receptor, alpha | |
| Monoclonal | |
| Unconjugated | |
| PBS with no preservative; pH 7.4 | |
| NM_000964 | |
| RARA | |
| RARA (NP_000955, 315 a.a. ∼ 424 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | |
| 100 μg | |
| Transcription Regulation | |
| Primary | |
| Human | |
| Antibody |
| ELISA, Immunohistochemistry (PFA fixed), Western Blot | |
| 2D2 | |
| Mouse monoclonal antibody raised against a partial recombinant RARA. | |
| RARA | |
| NR1B1/RAR | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Yes | |
| 5914 | |
| Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. | |
| IgG1 κ |