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beta-Estradiol, 99% (dry wt.), ca 3% water, Thermo Scientific Chemicals
Supplier: Thermo Scientific Chemicals L0380106
Description
β-Estradiol is the major estrogen secreted by the premenopausal ovary. It acts as an estrogenic hormone receptor (ER) agonist and activator of PI 3-kinase. Further, it is used in the treatment of infertility in women, prostate cancer and breast cancer. It is also employed as an agent of stimulating female puberty induction, as in the treatment of delayed puberty caused by hypogonadism or Turner's syndrome. In addition to this, it is used as part of the hormone replacement therapy for transgender women.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applicationsβ-Estradiol is the major estrogen secreted by the premenopausal ovary. It acts as an estrogenic hormone receptor (ER) agonist and activator of PI 3-kinase. Further, it is used in the treatment of infertility in women, prostate cancer and breast cancer. It is also employed as an agent of stimulating female puberty induction, as in the treatment of delayed puberty caused by hypogonadism or Turner′s syndrome. In addition to this, it is used as part of the hormone replacement therapy for transgender women.
Solubility
Soluble in dimethyl sulfoxide, ethanol , water, phosphate buffer saline, dimethyl formamide, acetone, dioxane and alkali hydroxides. Slightly soluble in vegetable oils.
Notes
Incompatible with strong oxidizing agents.
Specifications
| beta-Estradiol | |
| 175°C to 178°C | |
| C18H24O2 | |
| 5 g | |
| 14,3703 | |
| Soluble in dimethyl sulfoxide,ethanol ,water,phosphate buffer saline,dimethyl formamide,acetone,dioxane and alkali hydroxides. Slightly soluble in vegetable oils. | |
| +79° (c=1 in Dioxane) | |
| (8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol | |
| 5757 | |
| 272.39 |
| 50-28-2 | |
| (dry wt.), ≈3% water | |
| MFCD00003693 | |
| 1914275 | |
| estradiol, beta-estradiol, 17beta-estradiol, oestradiol, dihydrofolliculin, estrace, ovocyclin, progynon, dihydrotheelin, dihydroxyestrin | |
| VOXZDWNPVJITMN-ZBRFXRBCSA-N | |
| CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O | |
| 272.388 | |
| CHEBI:16469 | |
| 99% |
Chemical Identifiers
| 50-28-2 | |
| 272.388 | |
| VOXZDWNPVJITMN-ZBRFXRBCSA-N | |
| 5757 | |
| (8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol |
| C18H24O2 | |
| MFCD00003693 | |
| estradiol, beta-estradiol, 17beta-estradiol, oestradiol, dihydrofolliculin, estrace, ovocyclin, progynon, dihydrotheelin, dihydroxyestrin | |
| CHEBI:16469 | |
| CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O |
Safety and Handling
GHS H Statement
H350-H360
May cause cancer.
May damage fertility or the unborn child.
P201-P202-P260-P263-P264b-P270-P271-P281-P304+P340-P308+P313-P501c
H350-H361fd-H362-H373
EINECSNumber : 200-023-8
RTECSNumber : KG2975000
TSCA : No
Recommended Storage : Ambient temperatures
RUO – Research Use Only