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Bexarotene, 98%, Thermo Scientific Chemicals
Synthetic retinoid analog with specific affinity for the retinoid X receptor
$280.78 - $653.16
Chemical Identifiers
| CAS | 153559-49-0 |
|---|---|
| Molecular Formula | C24H28O2 |
| Molecular Weight (g/mol) | 348.49 |
| MDL Number | MFCD00932428 |
| InChI Key | NAVMQTYZDKMPEU-UHFFFAOYSA-N |
| Synonym | bexarotene, targretin, targrexin, targretyn, targret, bexarotenum, bexarotene usan, bexaroteno, bexaroten, targretin-gel |
| PubChem CID | 82146 |
| ChEBI | CHEBI:50859 |
| IUPAC Name | 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethenyl]benzoic acid |
| SMILES | CC1=CC2=C(C=C1C(=C)C1=CC=C(C=C1)C(O)=O)C(C)(C)CCC2(C)C |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
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AAJ63701MC
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Thermo Scientific Chemicals
J63701MC |
100 mg |
Each for $280.78
|
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AAJ63701EXH
|
Thermo Scientific Chemicals
J63701EXH |
300 mg |
Each for $653.16
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Description
Bexarotene is used as a Synthetic retinoid analog with specific affinity for the retinoid X receptor, an antineoplastic agent, already approved as an oral antineoplastic agent for cutaneous T cell lymphoma and being investigated against other cancers. A study has found that bexarotene in a mouse Alzheimer's model lowered the most toxic form of β-amyloid peptide and increased cognitive ability.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
ApplicationsBexarotene is used as a Synthetic retinoid analog with specific affinity for the retinoid X receptor, an antineoplastic agent, already approved as an oral antineoplastic agent for cutaneous T cell lymphoma and being investigated against other cancers. A study has found that bexarotene in a mouse Alzheimer′s model lowered the most toxic form of β-amyloid peptide and increased cognitive ability.
Solubility
Soluble in DMSO and ethanol
Notes
Store in cool, dry conditions in well sealed containers. Keep container tightly closed.
Chemical Identifiers
| 153559-49-0 | |
| 348.49 | |
| NAVMQTYZDKMPEU-UHFFFAOYSA-N | |
| 82146 | |
| 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethenyl]benzoic acid |
| C24H28O2 | |
| MFCD00932428 | |
| bexarotene, targretin, targrexin, targretyn, targret, bexarotenum, bexarotene usan, bexaroteno, bexaroten, targretin-gel | |
| CHEBI:50859 | |
| CC1=CC2=C(C=C1C(=C)C1=CC=C(C=C1)C(O)=O)C(C)(C)CCC2(C)C |
Specifications
| 153559-49-0 | |
| White | |
| MFCD00932428 | |
| 14,1194 | |
| Soluble in DMSO and ethanol | |
| CC1=CC2=C(C=C1C(=C)C1=CC=C(C=C1)C(O)=O)C(C)(C)CCC2(C)C | |
| 348.49 | |
| CHEBI:50859 | |
| ≥99% | |
| Bexarotene |
| 220°C to 225°C | |
| C24H28O2 | |
| 100 mg | |
| bexarotene, targretin, targrexin, targretyn, targret, bexarotenum, bexarotene usan, bexaroteno, bexaroten, targretin-gel | |
| NAVMQTYZDKMPEU-UHFFFAOYSA-N | |
| 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethenyl]benzoic acid | |
| 82146 | |
| 348.48 | |
| Powder |
Safety and Handling
GHS H Statement
H302-H315-H319-H335
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c
H302-H315-H319-H335
RTECSNumber : DH6834830
TSCA : No
Recommended Storage : Store at -20°C
RUO – Research Use Only