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Chloromethyl pivalate, 97%, Thermo Scientific Chemicals

$55.52 - $152.32

Chemical Identifiers

CAS 18997-19-8
Molecular Formula C6H11ClO2
Molecular Weight (g/mol) 150.60
MDL Number MFCD00000884
InChI Key GGRHYQCXXYLUTL-UHFFFAOYSA-N
Synonym chloromethyl pivalate, propanoic acid, 2,2-dimethyl-, chloromethyl ester, pivalic acid chloromethyl ester, pivaloyloxymethyl chloride, pivaloylmethyl chloride, chloromethyl trimethylacetate, 2,2-dimethylpropionic acid chloromethyl ester, chioromethyl pivalate, chloromethyl pivaloate, chloro-methyl pivalate
PubChem CID 87885
IUPAC Name chloromethyl 2,2-dimethylpropanoate
SMILES CC(C)(C)C(=O)OCCl
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
AAA1196714
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Thermo Scientific Chemicals
A1196714
25 g N/A
 
AAA1196722
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Thermo Scientific Chemicals
A1196722
100 g N/A
 
Description

Description

Chloromethyl pivalate acts as an intermediate in the synthesis of active pharmaceutical ingredients. It is also involved in the acylation reaction with 9-(2-phosphonylmethoxyethyl)adenine. It serves as a protecting reagent used for the N-protection of amines. It is also employed in the preparation of pivaloyloxy methyl ester of ofloxacin as a prodrug. Further, it is used to prepare sulbactam pivoxil by reaction with sodium salt of sulbactam. In addition to this, it is used as a reagent during the synthesis of an isoindoline-annulated and continuous-flow organic synthesis.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Chloromethyl pivalate acts as an intermediate in the synthesis of active pharmaceutical ingredients. It is also involved in the acylation reaction with 9-(2-phosphonylmethoxyethyl)adenine. It serves as a protecting reagent used for the N-protection of amines. It is also employed in the preparation of pivaloyloxy methyl ester of ofloxacin as a prodrug. Further, it is used to prepare sulbactam pivoxil by reaction with sodium salt of sulbactam. In addition to this, it is used as a reagent during the synthesis of an isoindoline-annulated and continuous-flow organic synthesis.

Solubility
Miscible with most organic solvents. Immiscible with water.

Notes
Incompatible with strong oxidizing agents.
Specifications

Chemical Identifiers

18997-19-8
150.60
GGRHYQCXXYLUTL-UHFFFAOYSA-N
87885
CC(C)(C)C(=O)OCCl
C6H11ClO2
MFCD00000884
chloromethyl pivalate, propanoic acid, 2,2-dimethyl-, chloromethyl ester, pivalic acid chloromethyl ester, pivaloyloxymethyl chloride, pivaloylmethyl chloride, chloromethyl trimethylacetate, 2,2-dimethylpropionic acid chloromethyl ester, chioromethyl pivalate, chloromethyl pivaloate, chloro-methyl pivalate
chloromethyl 2,2-dimethylpropanoate

Specifications

18997-19-8
146°C to 148°C
C6H11ClO2
(CH3)3CCO2CH2Cl
25 g
1560838
Miscible with most organic solvents. Immiscible with water.
CC(C)(C)C(=O)OCCl
150.60
150.6
Chloromethyl pivalate
1.045
40°C (104°F)
1.417
MFCD00000884
UN2924
chloromethyl pivalate, propanoic acid, 2,2-dimethyl-, chloromethyl ester, pivalic acid chloromethyl ester, pivaloyloxymethyl chloride, pivaloylmethyl chloride, chloromethyl trimethylacetate, 2,2-dimethylpropionic acid chloromethyl ester, chioromethyl pivalate, chloromethyl pivaloate, chloro-methyl pivalate
GGRHYQCXXYLUTL-UHFFFAOYSA-N
chloromethyl 2,2-dimethylpropanoate
87885
97%
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Safety and Handling

Safety and Handling

GHS H Statement
H314-H318-H226
Causes severe skin burns and eye damage.
Causes serious eye damage.
Flammable liquid and vapor.

P210-P233-P235-P240-P241-P242-P243-P260-P264b-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P370+P378q-P501c

H226-H302-H312-H314-H332-H335

DOTInformation : Transport Hazard Class: 3; Packing Group: III; Proper Shipping Name: FLAMMABLE LIQUIDS, CORROSIVE, N.O.S.

EINECSNumber : 242-735-1

TSCA : Yes

Recommended Storage : Ambient temperatures

SDS
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RUO – Research Use Only