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(+/-)-Equol, Thermo Scientific Chemicals
Urinary metabolite of daidzein, produced by humans and horses
$348.29 - $348.29
Chemical Identifiers
| CAS | 94105-90-5 |
|---|---|
| Molecular Formula | C15H14O3 |
| Molecular Weight (g/mol) | 242.27 |
| MDL Number | MFCD00016662 |
| InChI Key | ADFCQWZHKCXPAJ-UHFFFAOYNA-N |
| Synonym | 3-4-hydroxyphenyl chroman-7-ol, equol, +/--equol, r,s-equol, 7,4'-homoisoflavane, 4',7-dihydroxyisoflavane, rs-equol, 3-4-hydroxyphenyl-7-chromanol, 2h-1-benzopyran-7-ol, 3,4-dihydro-3-4-hydroxyphenyl, 4',7-isoflavandiol |
| PubChem CID | 382975 |
| IUPAC Name | 3-(4-hydroxyphenyl)-3,4-dihydro-2H-chromen-7-ol |
| SMILES | OC1=CC=C(C=C1)C1COC2=C(C1)C=CC(O)=C2 |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity | |||||
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AAJ61383MC
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Thermo Scientific Chemicals
J61383MC |
100 mg |
Each for $348.29
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Description
(±)-Equol exhibits EC50 values of 200 and 74 nM for human ERα and ERβ, respectively and induces breast cancer cell proliferation in vitro at concentrations as low as 100 nM. It is a weak estrogenic agonist, and competitive inhibitor of 17β-estradiol at the estradiol receptor. It inhibits 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced neoplastic cell transformation by targeting the MEK/ERK/p90RSK/activator protein-1 signalling pathway. It functions as a DHT blocker.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications(+/-)-Equol exhibits EC50 values of 200 and 74 nM for human ERα and ERβ, respectively and induces breast cancer cell proliferation in vitro at concentrations as low as 100 nM. It is a weak estrogenic agonist, and competitive inhibitor of 17β-estradiol at the estradiol receptor. It inhibits 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced neoplastic cell transformation by targeting the MEK/ERK/p90RSK/activator protein-1 signalling pathway. It functions as a DHT blocker.
Solubility
Soluble in DMSO and methanol or 100% ethanol. Insoluble in water.
Notes
Hygroscopic. Incompatible with oxidizing agents and heat.
Chemical Identifiers
| 94105-90-5 | |
| 242.27 | |
| ADFCQWZHKCXPAJ-UHFFFAOYNA-N | |
| 382975 | |
| OC1=CC=C(C=C1)C1COC2=C(C1)C=CC(O)=C2 |
| C15H14O3 | |
| MFCD00016662 | |
| 3-4-hydroxyphenyl chroman-7-ol, equol, +/--equol, r,s-equol, 7,4'-homoisoflavane, 4',7-dihydroxyisoflavane, rs-equol, 3-4-hydroxyphenyl-7-chromanol, 2h-1-benzopyran-7-ol, 3,4-dihydro-3-4-hydroxyphenyl, 4',7-isoflavandiol | |
| 3-(4-hydroxyphenyl)-3,4-dihydro-2H-chromen-7-ol |
Specifications
| 94105-90-5 | |
| White | |
| MFCD00016662 | |
| 87752 | |
| 14,3644 | |
| Soluble in DMSO and methanol or 100% ethanol. Insoluble in water. | |
| OC1=CC=C(C=C1)C1COC2=C(C1)C=CC(O)=C2 | |
| 242.27 | |
| 242.27 | |
| (+/-)-Equol |
| 172°C to 176°C | |
| C15H14O3 | |
| 100 mg | |
| Hygroscopic | |
| 3-4-hydroxyphenyl chroman-7-ol, equol, +/--equol, r,s-equol, 7,4'-homoisoflavane, 4',7-dihydroxyisoflavane, rs-equol, 3-4-hydroxyphenyl-7-chromanol, 2h-1-benzopyran-7-ol, 3,4-dihydro-3-4-hydroxyphenyl, 4',7-isoflavandiol | |
| ADFCQWZHKCXPAJ-UHFFFAOYNA-N | |
| 3-(4-hydroxyphenyl)-3,4-dihydro-2H-chromen-7-ol | |
| 382975 | |
| Crystalline Powder |
Safety and Handling
TSCA : No
Recommended Storage : Store at -20°C
RUO – Research Use Only