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Etoposide, Thermo Scientific Chemicals
Topoisomerase inhibitor and inducer of apoptosis
Supplier: Thermo Scientific Chemicals J63651MC
Description
Etoposide is used as a inhibits DNA synthesis and is very active against cells in the late S and G2 phases of the cell cycle. Etoposide was reported to be used to serum starve Saos-2 M5(p53-/-) cells which were transfected by electroporation with indicated expression plasmids for flag-E2F1 and myc-EBNA3C for selection of colony forming units, thus studying the blocking effect of EBV Nuclear Antigen 3C on E2F1 Mediated Apoptosis Induced by the DNA Damage Response.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
ApplicationsEtoposide is used as a inhibits DNA synthesis and is very active against cells in the late S and G2 phases of the cell cycle. Etoposide was reported to be used to serum starve Saos-2 M5(p53-/-) cells which were transfected by electroporation with indicated expression plasmids for flag-E2F1 and myc-EBNA3C for selection of colony forming units, thus studying the blocking effect of EBV Nuclear Antigen 3C on E2F1 Mediated Apoptosis Induced by the DNA Damage Response.
Solubility
Insoluble in water.
Notes
Store solutions in DMSO at 4°C. For long term storage prepare aliquots and store at -20°C.
Specifications
| Etoposide | |
| 236°C to 251°C | |
| C29H32O13 | |
| 100 mg | |
| vjjpusntgommgy-nzlmilqcsa | |
| VJJPUSNTGOMMGY-MRVIYFEKSA-N | |
| COC1=CC(=CC(OC)=C1O)[C@H]1[C@@H]2[C@H](COC2=O)[C@H](O[C@@H]2O[C@@H]3CO[C@@H](C)O[C@H]3[C@H](O)[C@H]2O)C2=CC3=C(OCO3)C=C12 | |
| 588.56 | |
| 588.56 |
| 33419-42-0 | |
| White | |
| MFCD00869325,MFCD00869325 | |
| 14,3886 | |
| Insoluble in water. | |
| −107° (c=1 in Methanol/Dichloromethane 1:9) | |
| (10R,11R,15R,16S)-16-{[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-hexahydro-2H-pyrano[3,2-d][1,3]dioxin-6-yl]oxy}-10-(4-hydroxy-3,5-dimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0³,â·.0¹¹,¹âµ]hexadeca-1,3(7),8-trien-12-one | |
| 50936917 | |
| Powder |
Chemical Identifiers
| 33419-42-0 | |
| 588.56 | |
| VJJPUSNTGOMMGY-MRVIYFEKSA-N | |
| 50936917 | |
| COC1=CC(=CC(OC)=C1O)[C@H]1[C@@H]2[C@H](COC2=O)[C@H](O[C@@H]2O[C@@H]3CO[C@@H](C)O[C@H]3[C@H](O)[C@H]2O)C2=CC3=C(OCO3)C=C12 |
| C29H32O13 | |
| MFCD00869325,MFCD00869325 | |
| vjjpusntgommgy-nzlmilqcsa | |
| (10R,11R,15R,16S)-16-{[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-hexahydro-2H-pyrano[3,2-d][1,3]dioxin-6-yl]oxy}-10-(4-hydroxy-3,5-dimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0³,â·.0¹¹,¹âµ]hexadeca-1,3(7),8-trien-12-one |
Safety and Handling
GHS H Statement
H350-H302
May cause cancer.
Harmful if swallowed.
P201-P202-P264b-P270-P281-P301+P312-P308+P313-P330-P501c
H302-H350
EINECSNumber : 251-509-1
RTECSNumber : KC0190000
TSCA : No
Recommended Storage : Ambient temperatures
RUO – Research Use Only