Invitrogen™ ICAM-1 Polyclonal Antibody

Description

Immunogen sequence: EAHPRAKVTL NGVPAQPLGP RAQLLLKATP EDNGRSFSCS ATLEVAGQLI HKNQTRELRV LYGPRLDERD CPGNWTWPEN SQQTPMCQAW GNPLPELKCL KDGTFPLPIG ESVTVTRDLE GTYLCRARST QGEVTRKVTV NVLSP Highest antigen sequence indentity to the following orthologs: Mouse - 55%, Rat - 49%.

ICAM-1 (CD54) is an 85-110 kDa single-chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. ICAM-1 has 7 potential N-linked glycosylation sites and shares considerable amino acid sequence homology with ICAM-3 (CD50) and ICAM-2 (CD102). ICAM-1 binds to integrins of type CD11a/CD18 (leukocyte adhesion molecule, LFA-1), or CD11b/CD18 (Mac-1) and is exploited by Rhinovirus as a receptor. ICAM-1 is expressed by activated endothelial cells and detected on epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase upon inflammation. ICAM-1 is also detected in some carcinoma and melanoma cells. Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes.