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Methicillin sodium salt, 90+%, Thermo Scientific Chemicals
Supplier: Thermo Scientific Chemicals J6641403
Description
Targets primarily the cell wall of Gram-positive organisms especially Staphylococcus aureus. Methicillin is used to study bacterium susceptibility, and to inhibit cell-wall synthesis. PBP's are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Methicillin Sodium Salt is inactivated by gastric acid so it is given to cells by other means in which gastric acid is not present in vitro.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
ApplicationsTargets primarily the cell wall of Gram-positive organisms especially Staphylococcus aureus. Methicillin is used to study bacterium susceptibility, and to inhibit cell-wall synthesis. PBP′s are enzymes which catalyze a pentagl
Specifications
| Methicillin Sodium Salt | |
| Powder | |
| 196°C to 197°C (decomposition) | |
| MFCD07787409 | |
| Sodium (2,6-dimethoxyphenyl)penicillin; Sodium methicillin | |
| MGFZNWDWOKASQZ-UMLIZJHQSA-M | |
| sodium (2S,5R,6R)-6-(2,6-dimethoxybenzamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate | |
| 23667627 | |
| 402.4 | |
| White | |
| >110°C (230°F) | |
| 640°C |
| Methicillin sodium salt | |
| 132-92-3 | |
| C17H19N2NaO6S | |
| 14,5969 | |
| Slightly soluble in acetone; Soluble in ethanol or water | |
| [Na+].COC1=CC=CC(OC)=C1C(=O)N[C@H]1[C@H]2SC(C)(C)[C@@H](N2C1=O)C([O-])=O | |
| 402.40 | |
| CHEBI:52065 | |
| 98% | |
| 1 g | |
| Light sensitive |
Chemical Identifiers
| 132-92-3 | |
| 402.40 | |
| MGFZNWDWOKASQZ-UMLIZJHQSA-M | |
| 23667627 | |
| sodium (2S,5R,6R)-6-(2,6-dimethoxybenzamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| C17H19N2NaO6S | |
| MFCD07787409 | |
| Sodium (2,6-dimethoxyphenyl)penicillin; Sodium methicillin | |
| CHEBI:52065 | |
| [Na+].COC1=CC=CC(OC)=C1C(=O)N[C@H]1[C@H]2SC(C)(C)[C@@H](N2C1=O)C([O-])=O |
Safety and Handling
GHS H Statement
H334-H335-H315-H319-H317
May cause allergy or asthma symptoms or breathing difficulties if inhaled.
May cause respiratory irritation.
Causes skin irritation.
Causes serious eye irritation.
May cause an allergic skin reaction.
P261-P264b-P271-P272-P280-P285-P302+P352-P304+P340-P305+P351+P338-P333+P313-P342+P311-P362-P501c
H315-H317-H319-H334-H335
EINECSNumber : 205-083-9
RTECSNumber : XH8950000
TSCA : No
storageNote1 : -30° to -10°C
Recommended Storage : Store at -20°C
RUO – Research Use Only