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Thermo Scientific™ Pierce™ Hydroxylamine-HCl
NH2OH (CAS 7803-49-8) to cleave Asn-Gly peptide bonds or deprotect sulfhydryls following S-acetylthioacetate modification with SATA reagent.
Supplier: Thermo Scientific™ 26103
Description
Thermo Scientific™ Pierce Hydroxylamine-HCl has many uses, including to cleave Asn-Gly peptide bonds and to deprotect (expose) sulfhydryls for conjugation following modification with SATA and similar reagents.
Thermo Scientific™ Pierce Hydroxylamine-HCl has many uses, which include cleaving Asn-Gly peptide bonds and deprotecting (exposing) sulfhydryls on SATA-modified molecules for conjugation. Hydroxylamine·HCl is a strong reducing agent that is useful in biochemical crosslinking applications, including the deacetylation of SATA and chemical cleavage of EGS and Sulfo-EGS. Hydroxylamine converts carbonyl compounds (aldehydes and ketones) to their oxime derivatives in the presence of a weak base. Therefore, crosslinkers and other compounds that contain a carbonyl within their structure are cleavable with hydroxylamine-HCl.
Highlights:
- Exposes protected sulfhydryl groups on SATA-modified molecules
- Cleaves carbonyl-containing crosslinkers such as EGS
Reagent Properties:
- Chemical name: Hydroxylamine Hydrochloride
- Chemical formula: NH2OH·HCl
- Molecular weight: 69.49
- CAS Number: 5470-11-1
- Form: White crystals, free of foreign material
- Solubility: 10%
Specifications
| 5470-11-1 | |
| Pierce™ | |
| SATA | |
| Hydroxylamine Hydrochloride |
| Upon receipt store desiccated at room temperature. Product shipped at ambient temperature. | |
| Solid | |
| 25 g |
For Research Use Only. Not for use in diagnostic procedures.