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Scopolamine hydrobromide trihydrate, 99%, Thermo Scientific Chemicals
Scopolamine hydrobromide trihydrate, CAS # 6533-68-2, is the trihydrate form of scopolamine hydrobromide that shows competitive anti-muscarinic activity by blocking the actions of endogenous acetylcholine or exogenous agonists. It also shows anti-spasmodic and anti-emetic activities.
Supplier: Thermo Scientific Chemicals 161750050
Description
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Information
• Scopolamine hydrobromide trihydrate is a salt form of scopolamine, a tropane alkaloid derived from plants of the nightshade family (Solanaceae), mainly Hyoscyamus niger and Atropa belladonna
• Scopolamine hydrobromide trihydrate, demonstrates competitive anti-muscarinic activity blocking the actions of endogenous acetylcholine or exogenous agonists
• It also shows anti-spasmodic and anti-emetic activities
Applications
• It has been described that scopolamine inhibits muscarinic acetylcholine receptors (mAChRs) with some selectivity for M1 mAChRs
• It is structurally similar to acetylcholine and can antagonize acetylcholine activity mediated by muscarinic receptors located on structures innervated by postganglionic cholinergic nerves and on smooth muscles (that respond to acetylcholine but lack cholinergic innervation)
• Scopolamine hydrobromide trihydrate can induce amnesia in laboratory animals and so it is frequently used in animal models of memory deficit
• Scopolamine hydrobromide trihydrate is used to induce cognitive deficits in animal models of Alzheimer’s disease
• Scopolamine, has been employed in several studies to understand, identify, and characterize biological targets for Alzheimer's disease
Specifications
| Scopolamine hydrobromide trihydrate | |
| 6533-68-2 | |
| White or Colorless | |
| 99% | |
| C17H28BrNO7 | |
| 5 g | |
| 14, 8406 | |
| − 27.00 | |
| Solubility in water: 700g/L water (20 c). Other solubilities: 1g/20 mL alcohol, slightly soluble in chloroform, practically insoluble in ether | |
| [H+].O.O.O.[Br-].CN1[C@H]2CC(C[C@H]1[C@@H]1O[C@H]21)OC(=O)[C@H](CO)C1=CC=CC=C1 | |
| 438.32 | |
| 438.3 | |
| Crystalline Powder or Crystals |
| 99% | |
| 194.0°C to 197.0°C | |
| Authentic | |
| Glass bottle | |
| MFCD00150066 | |
| 27, 102 | |
| −27° (20°C c=5,H2O) | |
| hyoscine hydrobromide trihydrate | |
| LACQPOBCQQPVIT-FCFGRTKISA-N | |
| hydrogen (1S,2R,4S,5S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0²,â´]nonan-7-yl (2S)-3-hydroxy-2-phenylpropanoate trihydrate bromide | |
| 131632304 | |
| 99% |
Chemical Identifiers
| 6533-68-2 | |
| 438.32 | |
| LACQPOBCQQPVIT-FCFGRTKISA-N | |
| 131632304 | |
| [H+].O.O.O.[Br-].CN1[C@H]2CC(C[C@H]1[C@@H]1O[C@H]21)OC(=O)[C@H](CO)C1=CC=CC=C1 |
| C17H28BrNO7 | |
| MFCD00150066 | |
| hyoscine hydrobromide trihydrate | |
| hydrogen (1S,2R,4S,5S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0²,â´]nonan-7-yl (2S)-3-hydroxy-2-phenylpropanoate trihydrate bromide |
Safety and Handling
GHS H Statement:
Fatal if inhaled.
Fatal if swallowed.
Fatal in contact with skin.
GHS P Statement:
IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
Wear protective gloves/protective clothing/eye protection/face protection.
Remove/Take off immediately all contaminated clothing.
IF ON SKIN: Gently wash with plenty of soap and water.
Immediately call a POISON CENTER or doctor/physician.
IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.
GHS Signal Word: Danger
RTECSNumber : YM4730000
RUO – Research Use Only