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Tolbutamide, 98%, Thermo Scientific Chemicals

Supplier:  Thermo Scientific Chemicals B2169809

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Catalog No. AAB2169809


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Description

Description

Tolbutamide, have been used in a cDNA microarray assay to probe changes in gene expression in HepG2 cells upon their administration. It has been utilized to counteract insulin activity in a patch-clamp investigation of ATP sensitive K+ channels in mouse pancreatic β-cells. The activity of various biotransformation enzymes in cultured primary rat proximal tubular cells in the presence of tolbutamide and other compounds has been studied.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Tolbutamide, have been used in a cDNA microarray assay to probe changes in gene expression in HepG2 cells upon their administration. It has been utilized to counteract insulin activity in a patch-clamp investigation of ATP sensitive K+ channels in mouse pancreatic β-cells. The activity of various biotransformation enzymes in cultured primary rat proximal tubular cells in the presence of tolbutamide and other compounds has been studied.

Solubility
Soluble in chloroform.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.
Specifications

Specifications

Tolbutamide
128°C to 130°C
MFCD00027169
1984428
tolbutamide, orinase, 1-butyl-3-tosylurea, tolbutamid, aglicid, arkozal, artosin, diabetol, dolipol, rastinon
JLRGJRBPOGGCBT-UHFFFAOYSA-N
1-butyl-3-(4-methylphenyl)sulfonylurea
5505
270.35
64-77-7
C12H18N2O3S
10 g
14,9507
Soluble in chloroform.
CCCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)C
270.347
CHEBI:27999
98%

Chemical Identifiers

64-77-7
270.347
JLRGJRBPOGGCBT-UHFFFAOYSA-N
5505
1-butyl-3-(4-methylphenyl)sulfonylurea
C12H18N2O3S
MFCD00027169
tolbutamide, orinase, 1-butyl-3-tosylurea, tolbutamid, aglicid, arkozal, artosin, diabetol, dolipol, rastinon
CHEBI:27999
CCCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)C
Safety and Handling

Safety and Handling

GHS H Statement
H302-H317
Harmful if swallowed.
May cause an allergic skin reaction.

P261-P264b-P270-P272-P280g-P301+P312-P302+P352-P330-P333+P313-P363-P501c

H302-H317

EINECSNumber : 200-594-3

RTECSNumber : YS4550000

TSCA : Yes

Recommended Storage : Ambient temperatures

SDS
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RUO – Research Use Only